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KMID : 0369820100400050263
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Jorunal of Korean Pharmaceutical Sciences
2010 Volume.40 No. 5 p.263 ~ p.267
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The Functional Behaviors of Cosurfactant in Design of Self-nanoemulsifying Drug Delivery Systems
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Yang Su-Geun
Shin Hee-Jong
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Abstract
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Nanoemulsions have been widely investigated for many years because of their attractive and unique characteristics. Nanoemulsions are composed of oil, surfactant, co-surfactant and water. Especially, cosurfactant plays a critical role in formation of nanoemulsions. In pharmaceutical area, a pre-concentrate form of nanoemulsions which is known as self-nanoemulsifying drug delivery systems (SNEDDS) was available for some water-insoluble drugs. In this study, we investigated the functional behaviors of cosurfactant in design of SNEDDS and nanoemulsions. Cremophor RH 40(R), Propylene carbonate and medium chain triglyceride were selected for surfactant, cosurfactant and oil, respectively. Cyclosporine was employed as a drug. Phase diagrams showed the area of isotropic o/w region which forms o/w nanoemulsions was not significantly affected by the compositional ratio of cosurfactant. But, drug solubilization capacity, droplet size of nanoemulsions and drug release rate were greatly affected by the cosurfactant.
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KEYWORD
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Cyclosporine, Cosurfactant, Nanoemulsions, SNEDDS (self-nanoemulsifying drug delivery system)
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